Should I Use BCL6 Testing After IVF Failure?

Read Time:3 Minute, 2 Second

In vitro fertilization (IVF) is an assisted reproductive technology that helps couples struggling with infertility to conceive. Despite IVF’s high success rates, it can sometimes fail.

After experiencing an IVF failure, understanding the reasons behind the failure can help patients explore alternative treatment options. One treatment option is BCL6 testing, a diagnostic tool that helps identify potential issues with the lining of the uterus after IVF failure.

What Is BCL6 Testing?

BCL6 testing helps identify problems with the uterus that could prevent successful implantation. It measures the expression of specific genes in the uterus lining to determine its receptivity for embryo implantation.

The test involves taking a biopsy of the uterine lining during a woman’s menstrual cycle and analyzing the tissue for genetic markers associated with successful pregnancy outcomes.

By examining these genetic markers, fertility specialists can determine whether or not there are abnormalities in the endometrium that may be preventing implantation.

Why Use BCL6 Testing After IVF Failure?

IVF failure occurs when the treatment does not lead to a healthy and successful pregnancy. This can be due to low sperm or egg quality, implantation failure, no embryo formation, genetic abnormalities, or hormonal imbalance.

BCL6 tests identify endometrial abnormalities like endometritis that may contribute to unexplained infertility or recurrent pregnancy loss. Here are a few reasons BCL6 testing may be helpful after a failed IVF cycle:

Endometrial Receptivity Assessment

BCL6 testing evaluates the molecular profile of endometrium, specifically its receptivity. Endometrial receptivity is the endometrium state that is most conducive to embryo implantation during the menstrual cycle. An endometrial receptivity assessment involves evaluating the lining of the uterus to determine its readiness for embryo implantation.

Professionals analyze the expression level of B-cell lymphoma 6 protein, which regulates endometrial receptivity. By examining the BCL6 expression pattern, fertility specialists identify the optimal endometrial receptivity period within the menstrual cycle.

This allows for more accurate timing of embryo transfer, maximizing the chances of successful and healthy implantation and pregnancy.

Uterine Pathologies Identification

Uterine pathologies, such as endometriosis, can be identified through BCL6 testing. Endometriosis is a condition characterized by endometrial-like tissues growing outside the uterus. These tissues respond to hormonal changes during the menstrual cycle, causing inflammation.

The common symptoms of endometriosis are pelvic pain, pain during intercourse, and painful periods. If left untreated, endometriosis may lead to unexplained infertility or recurrent pregnancy loss. This is because the endometrial tissues interfere with embryo implantation and subsequent pregnancy.

BCL6 testing identifies endometrial overexpression conditions linked with endometriosis. The endometrial expression may occur due to hormonal imbalances or inflammatory responses.

If a fertility specialist detects endometriosis, they may recommend treatments like hormonal therapies and surgical procedures to remove endometriotic lesions. This enhances the likelihood of achieving successful embryo implantation in future IVF cycles.

Personalized Treatment Approach

A BCL6 test identifies uterine lining inflammation linked with endometriosis that may have gone unnoticed in previous treatments. The test gives fertility specialists insight into the endometrium’s health. This insight allows them to create targeted treatment plans that address each patient’s fertility issues.

These treatment plans may include hormonal supplementation, endometriosis scratch, or uterine perfusion technique. Personalized treatment care enhances the precision of fertility intervention, improving embryo implantation and pregnancy outcomes.

Learn More About BCL6 Testing

Patients who have experienced failed IVF cycles or recurrent miscarriages may be good candidates for BCL6 testing. By identifying potential issues with the uterine lining, fertility specialists develop individualized treatment plans to help increase the chances of a successful pregnancy outcome.

Contact a fertility clinic today to schedule a consultation and learn more about BCL6 testing and other available treatment options after a failed IVF round.